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Inventi Impact: Molecular Modeling

Articles

  • Inventi:pmm/18501/16
    In-vitro Test and Molecular Docking of Alkaloid Compound in Marine Sponge Cinachyrella anomala\nagainst T47D Cell Cycle
    01-Jan-1970 Research 2016 : January - March
    Awik Puji Dyah Nurhayati, Rarastoeti Pratiwi, Subagus Wahyuono, Istriyati, Hari Purnomo, Syamsudin Abdillah

    The compound 1,4,9-triazatricyclo[7,3,1,0]trideca-3,5(13),10-trien-8-ol (SA2014) was isolated from the marine sponge Cinachyrella anomala. In vitro assay for SA2014 compound was found to be able to induce cell-cycle arrest at the sub-G1 and G2/M phases of T47D cancerous cell. A combined dosage between of SA2014 compound and of doxorubicin was able to induce cell-cycle arrest at sub-G1 and G2/M phases. Molecular docking approach showed that SA2014 compound inhibited cdk2 enzyme. The strength of interaction between SA2014 and cdk2 (docking score = -65,43) was more stable than the interaction between doxorubicin and cdk2 (-36,59).

    How to Cite this Article
    CC Compliant Citation: Nurhayati APD, Pratiwi R, Wahyuono S, Istriyati, Purnomo H, et al. (2015) In Vitro Test and Molecular Docking of Alkaloid\nCompound in Marine Sponge Cinachyrella anomala against T47D Cell Cycle. J Marine Sci Res Dev 5: 158. doi:10.4172/2155-9910.1000158,\nhttp://creativecommons.org/licenses/.
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